Piperine ameliorates SCA17 neuropathology by reducing ER stress
نویسندگان
چکیده
منابع مشابه
Klotho ameliorates chemically induced endoplasmic reticulum (ER) stress signaling.
BACKGROUND Both endoplasmic reticulum (ER) stress, a fundamental cell response associated with stress-initiated unfolded protein response (UPR), and loss of Klotho, an anti-aging hormone linked to NF-κB-induced inflammation, occur in chronic metabolic diseases such as obesity and type 2 diabetes. We investigated if the loss of Klotho is causally linked to increased ER stress. METHODS We treat...
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OBJECTIVE The lysosomal storage disease alpha-mannosidosis is caused by the deficiency of the lysosomal acid hydrolase alpha-mannosidase (LAMAN) leading to lysosomal accumulation of neutral mannose-linked oligosaccharides throughout the body, including the brain. Clinical findings in alpha-mannosidosis include skeletal malformations, intellectual disabilities and hearing impairment. To date, no...
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ژورنال
عنوان ژورنال: Molecular Neurodegeneration
سال: 2018
ISSN: 1750-1326
DOI: 10.1186/s13024-018-0236-x